Lysophosphatidic Acid Regulation and Roles in Human Prostate Cancer
Abstract
Lysophosphatidic acid (LPA) is a major mitogen in serum that regulates an array of cellular processes related to pathogensis of cancer, especially ovarian, prostate and breast cancer. Interest in LPA has accelerated recently with the discovery that it is a ligand of a family of three G protein coupled cell surface receptors. Prostate cancer cells express these LPA receptors and it has been suggested that their expression correlates with more advanced prostate cancer. We found that androgen markedly upregulates express of LPA(3) in LNCaP cells which are androgen-responsive prostate cancer cells, making them more similar to early stage carcinoma. In this grant period, we cloned a novel type of lipid kinase (MDGK) which phosphorylates monoacylglycerols and diacylglycerols to form LPA and PA, respectively. Both have been implicated in growth and survival of prostate cancer cells. Using a matched human tumor/normal tissue expression array, we found that MDGK expression was strikingly upregulated in prostate cancers compared to the normal prostate tissues from the same patient. In contrast, MDGK was similarly expressed in other types of cancers compared to their normal tissue counterparts, including kidney, breast, colon, and stomach cancers.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2005
- Accession Number
- ADA434263
Entities
People
- Sarah Spiegel
Organizations
- Virginia Commonwealth University