Multifunctional Magnetic Nanoparticle Probes for Deep-Tissue Imaging

Abstract

The goal of the DARPA-AFOSR project is to develop multifunctional magnetic nanoparticle probes for deep-tissue imaging using MRI. The specific objectives of the Phase 1 project include: (1) to functionalize iron-oxide magnetic nanoparticles for bioconjugation of oligonucleotides and peptides; (2) proof-of-concept demonstration of the signal transduction mechanism based on nanoprobe clustering on mRNA target; (3) to develop peptide-based delivery of magnetic nanoprobes into living cells with high delivery efficiency; (4) to perform preliminary MRI studies of detection sensitivity and signal-to-noise ratio in solution and in cells. This innovative molecular imaging approach integrates in vivo delivery, targeting/sensing and signal transduction; it has the potential to revolutionize medical imaging, diagnosis, and therapeutics with many DoD applications.

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Document Details

Document Type
Technical Report
Publication Date
Jun 08, 2005
Accession Number
ADA434280

Entities

People

  • Gang Bao

Organizations

  • Emory University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Chemical Synthesis
  • Chemistry
  • Clustering
  • Computer Simulations
  • Contrast
  • Detection
  • Efficiency
  • Engineering
  • Hybridization
  • Iron
  • Iron Oxides
  • Magnetic Nanoparticles
  • Measurement
  • Mechanical Engineering
  • Metal Oxide Nanoparticles
  • Nanoparticles
  • Nucleic Acids

Fields of Study

  • Physics

Readers

  • Medical Imaging.
  • Nanocomposite Materials Science

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech