Humanizing the Mouse Androgen Receptor to Study Polymorphisms and Mutations in Prostate Cancer

Abstract

Androgen receptor (AR) is a critical component in prostrate oncogenesis. AR alleles varying in length of the Nterminal glutamine (Q) tract carry distinct disease risks. Mutation of AR in tumors may influence androgen independence and resistance to treatment. Difficulties studying cancer initiation and progression are partly overcome with transgenic mouse tumor models. However, the mouse AR N-terminus differs significantly from human.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2005
Accession Number
ADA434360

Entities

People

  • Diane Robins

Organizations

  • University of Michigan

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Androgen Receptors
  • Biomedical Research
  • Chemistry
  • Disease Attributes
  • Dna Microarrays
  • Fertility
  • Genetic Variation
  • Genetics
  • Medical Genetics
  • Michigan
  • Neoplasms
  • Physiology
  • Prostate Cancer
  • Resistance
  • Stem Cells
  • Tissues

Fields of Study

  • Biology

Readers

  • Molecular and genetic basis of cancer.
  • Prostate Cancer Biology.