Immune Cells, If Rendered Insensitive to Transforming Growth Factor-Beta, Can Cure Prostate Cancer

Abstract

The objective of the current proposal is to perform immunotherapy to eradicate prostate cancer and at the same time to avoid the development of autoimmune disease, The proposal contains two tasks. The first task is a combination of IL-2 based tumor-reactive T-cell adoptive therapy with the TGF-beta based gene therapy for the treatment of mouse prostate cancer. The second task is A tetracycline inducible TGF-beta based gene therapy. At the time of this reports, we have completed Task 1 and a paper has been accepted by Cancer Research for publication in its March 1, 2005, issue. Currently, we are in the process of conducting studies described in Task 2.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2005
Accession Number
ADA434561

Entities

People

  • Chung Lee

Organizations

  • Northwestern University

Tags

DTIC Thesaurus Topics

  • Anti-Bacterial Agents
  • Autoimmune Diseases
  • Blood
  • Cancer
  • Cells
  • Culture Media
  • Diseases And Disorders
  • Gene Therapy
  • Growth Factors
  • Immune System
  • Lymphatic System
  • Lymphocytes
  • Peptide Growth Factors
  • Peptides
  • Prostate Cancer
  • Proteins
  • Tissues

Fields of Study

  • Medicine

Readers

  • Clinical Trial Research.
  • Molecular Biology and Genetics
  • Oncology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech