Nanobiohybrids: New Model Systems for Membranes and Sensors
Abstract
The focus of this program is to correlate structure and function in biological membranes using nanohybrids as artificial models and to develop new sensors based on nanohybrids. Nanohybrids artificial membranes exhibit characteristics similar to biological membranes and they can be used as sensors. The nanohybrids membranes are synthesized by intercalating amphiphile molecules into the galleries of a layered host producing an alternating amphiphile/inorganic multilayer. We have established how the nanohybrid membranes respond to changes in temperature, pH, pressure and electric field. For example, permeation through the nanohybrids can be modulated by changing the pH or by switching on and off the electric field across the membrane. We have also shown that the nanohybrid membranes can be used as sensors for different analytes including saccharine and quinine. Different responses have been observed even for molecules that have similar features for example, saccharin and its sodium salt suggesting that the nanohybrid might be useful in developing an electronic nose. The dynamic range of the current sensor for saccharin is 6 micro M to 500 micro M. Recent work has enabled us to optimize the response time (from several minutes to seconds) as well as better understand the sensing mechanism. We have found that the absorption of saccharin renders the membrane more hydrophilic. The more hydrophilic membrane allows for increased absorption of water molecules on both the surfaces and galleries of the membrane, which leads to changes in electrostatic field and polarization of the membrane.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2005
- Accession Number
- ADA434611
Entities
People
- Emmanuel P. Giannelis
Organizations
- Cornell University