Synthetic Lethality in Breast Cancer Cells: Genes Required for Tumor Survival

Abstract

The conversion of a normal cell into a cancer cell proceeds through a series of genetic and epigenetic alterations. We have proposed to use well established genetic methodologies to identify novel anti-cancer targets via their specific, genetic interactions with common cancer mutations. In short, we will identify genetic alterations that are neutral in normal cells, but that are lethal when combined with cancer mutations. This "synthetic lethality" approach may identify potential therapeutic targets that are highly specific to the cancer cell.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2004
Accession Number
ADA434625

Entities

People

  • Gregory Hannon

Organizations

  • Cold Spring Harbor Laboratory

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Breast Cancer
  • Cell Physiological Processes
  • Cells
  • Combination Therapy
  • Conversion
  • Demographic Cohorts
  • Diseases And Disorders
  • Genes
  • Genetic Phenomena
  • Genetics
  • Lethality
  • Mutations
  • Neoplasms
  • Survival
  • Therapy

Fields of Study

  • Biology

Readers

  • Molecular and genetic basis of cancer.

Technology Areas

  • Biotechnology