Fish Oil Supplementation and Fatty Acid Synthase Expression in the Prostate: A Randomized Controlled Trial
Abstract
One in seven men over age 60 will be diagnosed with prostate cancer. Elucidation of early cellular changes that may predict progression to prostate cancer and the identification of factors that may inhibit or reverse these cellular changes would be of great clinical significance. Dysregulation of lipid metabolism is an early cellular change that has recently come under investigation. Two lipid pathways will be explored in this study; 1)over-expression of the lipogenic enzyme fatty acid synthase (FAS) and 2) cholesterol accumulation in the specialized plasma membrane lipid rafts. Lipid rafts are rich in proteins that mediate signal transduction and are markers for aggressive prostate cancer. Cell culture research has demonstrated that dietary supplementation with polyunsaturated fatty acids, particularly omega-3 fatty acids, decreases expression of FAS and may alter the integrity of lipid raft formation. Treatment with cholesterol-lowering drugs, statins, has also been shown in animals to inhibit lipid raft formation and induce tumor cell death. We will conduct a randomized placebo-controlled study to evaluate the effect of fish oil, statin use and fish oil plus statin versus placebo on FAS expression and lipid raft composition in benign, pre-neoplastic and neoplastic prostate tissue from men undergoing repeat prostate biopsy.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2005
- Accession Number
- ADA434711
Entities
People
- Jackilen Shannon