P190-B, a Novel RhoGAP, in Mammary Gland Development and Breast Cancer Progression
Abstract
In our laboratory we investigate genes and signaling pathways that are critical for mammary gland development and function with the ultimate goal of understanding how these key pathways may be disrupted during breast cancer progression. P190B RhoGAP was identified as a gene that is preferentially expressed in the terminal end buds of the developing mammary gland. Previously we reported that loss of p190B function completely prevents ductal outgrowth in the mammary gland. This result suggests that regulated signaling of the Rho pathway downstream of p190B is essential for proper development of the mammary gland. The studies outlined in this proposal are aimed at further elucidating the role of p190B and the Rho signaling pathway in all stages of mammary gland development and the molecular mechanisms through which p190B acts to influence the different developmental stages in the mammary gland. The role of p190B and the Rho signaling pathway in breast cancer progression will also be investigated using a well-established mouse model of breast cancer, the MMTV-ErbB2 line of mice.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2004
- Accession Number
- ADA434797
Entities
People
- Tracy Vargo-gogola
Organizations
- Baylor College of Medicine