Chromatin Structure and Breast Cancer Radiosensitivity
Abstract
Most patients with breast cancer tolerate radiotherapy well with only limited acute, reversible adverse effects. However, about 5% of patients experience severe, delayed complications such as skin pigmentation changes, subcutaneous fibrosis, rib fractures, cardiac disease, pulmonary fibrosis, second primary cancer (specifically esophageal squamous-cell carcinoma as well as adenocarcinoma) and other complications, which manifest several years after treatment with ionizing radiation. Epidemiological studies have shown that irradiation of the breast especially among young women, increases the risk for subsequently developing breast cancer. It might thus be expected that genes that are known to influence radiation sensitivity may be associated with the radiotherapy related adverse effects.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2004
- Accession Number
- ADA434814
Entities
People
- Tej K. Pandita
Organizations
- Washington University in St. Louis