Cyclopentadienyl Rhenium (Technetium) Tricarbonyl Complexes Integrated in Estrogen Receptor Ligands for ER+ Tumor Imaging
Abstract
A class of breast tumors, known as ER+, contains significant concentrations of ER which functions to regulate cell growth, and mediate the action of estrogen antagonists. There is a need for the development non-invasive and reliable methods for the determination of tumor ER concentration in the identification of patients predicted to respond to hormone therapy. It has been shown that tumor ER concentration can be determined by imaging, using 18F-labeled ER selective ligands, and that the ER concentrations determined by imaging correlate well with those determined by immunoassay methods on surgical biopsies.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2004
- Accession Number
- ADA434829
Entities
People
- John Katzenellenbogen
- Nathan C. Ackroyd
Organizations
- University of Illinois Urbana–Champaign