Use of Epidermolysis Bullosa Biomarkers in Models of Vesicant Injury

Abstract

The chemical warfare agent sulfur mustard (HD) produces a delayed inflammatory response followed by blister formation in skin of exposed individuals. There is a similarity between HD-induced skin injury and the skin disease Epidermolysis Bullosa (EB) in both the morphology of the damage and the structural components involved. Both HD-induced injury and EB are believed to involve matrix metalloproteinases (MMPs), which play key roles in the disruption of connective tissue proteins and basement membrane proteins. The objectives of this study are to examine HD-induced changes in gene expression of MMP-2, MMP-9, and their substrates (laminin-gamma2, laminin-beta3, and laminin5-alpha3A) in skin from mice cutaneously exposed to HD and to determine the efficacy of specific MMP inhibitors to protect against HD injury.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2005
Accession Number
ADA434846

Entities

People

  • Carol L. Sabourin
  • Donald R. Gerecke

Organizations

  • Rutgers University–New Brunswick

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Chemical Reactions
  • Chemical Warfare
  • Chemical Warfare Agents
  • Chlorides
  • Diseases And Disorders
  • Ear
  • Gene Expression
  • Inhibitors
  • Magnification
  • Polymerase Chain Reaction
  • Skin Diseases
  • Statistical Analysis
  • Structural Components
  • Tissues
  • Vesicants

Fields of Study

  • Biology

Readers

  • Geochemistry
  • Molecular Biology and Genetics
  • Molecular and Cellular Biology