Enabling Technologies for Advanced Soft Tissue Modeling
Abstract
Soft tissue properties represent a major and significant unknown in the domain of medical modeling and simulation. This program presents a 4-year research effort in defining tissue characteristics of three distinct organs (liver, spleen, and kidney) in vivo. Over the course of this program, we will use novel methods of tissue interrogation to characterize non-linear behavior during slow deformations, as would commonly be seen during surgical manipulations. We will then develop mathematical models that can be optimized to permit near real-time representations of organ behaviors, including the boundary characteristics of organs in situ. Year 3 has seen: the beginning of the motorization of our large deformation indenter; data showing that our perfusion system supports tissue so that in vitro tests closely approximate in vivo tests; indications that we can capture and distinguish properties of the organ capsule and parenchyma with our small and large indentation devices,; development of a hybrid large-deformation and 3-D ultrasound scanning technique; FEM implementing a variety of non-linear constitutive laws; an image-based system for studying "knife-edge" plane strain deformation of tissues; extended gel phantom work from year 2 including international collaborations; acquisition of external funding to extend the vocal tissue measurement work from year 2.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2004
- Accession Number
- ADA435009
Entities
People
- Steven L. Dawson
Organizations
- Massachusetts General Hospital