MIC-1, A Potential Inhibitor of Breast Tumor Progression
Abstract
MIC-l is a member of the transforming growth factor-beta family of growth and differentiation factors. MIC-l is expressed in breast tissue and has numerous specific effects including inhibiting both breast development and breast duct proliferation. We hypothesize, therefore, that MIC-l may play a role in inhibiting breast cancer progression. In order to study this question we have generated genetically modified mi in which murine MIC-l expression is abolished (null mice). We are in the process of breeding these MIC-1 null mice with mouse lines that are predisposed to the development breast cancer and this will be examined in the upcoming year as a no-cost extension of this grant. We will analyze the effects of the absence of MIC-l on the rate of breast malignancy development in these animals comparing it to those that have intact MIC-l production. If our hypothesis is correct, MIC-l null mice will exhibit increased incide and/or severity of breast cancer. As such, these studies may identify an important anti tumor pathway in breast cancer, potentially providing novel strategies and targets for chemical therapeutics or diagnosis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2004
- Accession Number
- ADA435049
Entities
People
- Leonidas G. Koniaris
Organizations
- University of Miami