MR Imaging Based Treatment Planning for Radiotherapy of Prostate Cancer
Abstract
This work is aimed at MRI-based treatment planning for radiation therapy. The tasks for the first year include (a) quantify the effect of MRI distortion on target delineation and treatment planning dose calculation; (b) validate and improve gradient distortion correction for MRI-based treatment planning, (c) investigate the effect of intra-fraction prostate motion and (d) investigate the accuracy of a stereotactic body frame for patient immobilization. We have confirmed that treatment planning dose calculations using MRI- derived homogenous geometry are adequate for patient sizes within 38 cm using the GDC software. We have investigated the effect of MRI residual distortion after GDC on IMRT treatment planning and dosimetry accuracy. Our results showed that the residual distortion errors are < 1 cm, which will have a negligible clinical effect for> 90% of the prostate patients whose lateral dimensions are <40 cm. We have validated the residual distortions and developed computer software to reduce them using point-by point corrections for large patients (up to 42 cm). We have performed studies on the effect of intra-fraction prostate motion using MR cine images and we also have been evaluating the accuracy of a stereotactic body frame for patient immobilization using MRI.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2005
- Accession Number
- ADA435143
Entities
People
- Lili Chen
Organizations
- Fox Chase Cancer Center