Synthesis of Acetogenin Analogs as Potential Therapeutics for Treating Prostate Cancer
Abstract
New, flexible, economical, and practical syntheses of the natural products swuamotacin and bullatacin have been completed. The compounds have been submitted for biological testing, and preparation of analogs is underway. This work will provide much needed information on the structure activity relationships of this class of annonaceous acetogenins. The Promising and sometimes contradictory reports on the biological activity of the acetogenins will be solidly addressed in this work, and these findings will be essential tools in the exploitation of these compounds for their therapeutic potential in the flight against prostate cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2004
- Accession Number
- ADA435211
Entities
People
- Brian L. Pagenkopf
Organizations
- University of Texas at Austin