DU Fragment Carcinogenicity: Extrapolation of Findings in Rodents to Man
Abstract
Rats with implants of DU or injections of Thorotrast(Federal Registration) in muscles developed soft tissue sarcomas (STS). Tissue samples from this previously conducted life-span study were used to determine certain molecular changes associated with the STS induction. Significantly increased p53 expression was present in DU- induced STS compared with those induced by Thorotrast(Federal Registration). However, p53 expression was not found in the few microscopic tumors of the capsules around the implants or in benign tumors. Expression of the oncogenes MDM2, c-myc, and p2l was low and not related to DU or Thorotrast(Federal Registration). The oncogene K-ras was not mutated in any tumors. The pattern of differential gene expression in the DU-induced STS was not similar to the Thorotrast(Federal Registration)-induced STS. Few expressed genes were similar and many were exclusively expressed. These findings suggest that the mechanism of carcinogenesis is not the same for DU and Thorotrast(Federal Registration) induced STS. Histologic study of the embedded DU showed that the DU rapidly corrodes in muscle. In 7 days corrosion, and the acute tissue reaction to it, was visualized in radiographs of the tissues. Corrosion continued causing an enlargement of the embedded DU on radiographs. This information may be useful in interpreting radiographs of DU embedded in humans.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2004
- Accession Number
- ADA435231
Entities
People
- Fletcher F. Hahn
Organizations
- Lovelace Foundation