Investigating the Mechanisms of Action and the Identification of Breast Carcinogens by Computational Analysis of Female Rodent Carcinogena
Abstract
This project is investigating the potential that environmental estrogens may be involved in the etiology of breast cancer. We hypothesize that specific features of chemicals can be identified that are significantly associated with female and breast carcinogens and that these features are related to mechanisms of chemical carcinogenesis. Our overall scientific objective is to investigate the hypothesized relationship between environmental chemicals, xenoestrogens, and the development of breast cancer. With the success of the rat and mouse mammary carcinogen models we are preparing two manuscripts for publication. We are also pursuing work on a general chemical carcinogen manuscript and a one describing female-specific carcinogens. Also of importance, we are working on several xenoestrogen models that, although not detailed in the project proposal, will be of great importance for understanding the endocrine disruptor link to breast cancer. We have also developed a new structure-activity relationship program called cat-SAR that is producing predictive and mechanistically insightful models of mammary carcinogens. Looking forward I see no obstacles to the successful completion of this project in a timely manner.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2004
- Accession Number
- ADA435262
Entities
People
- Albert R. Cunningham
Organizations
- Louisiana State University