Novel Drug Delivery Technique for Breast Cancer Therapy
Abstract
This report describes the progress achieved during the third year of the project. We proposed to complete Task 3 and to implement Task 4 in the third year of the project. Task 3 focuses on in vivo studies of efficacy of cancer therapy with the use of ultrasound-enhanced delivery of anti-cancer drug 5-FU (low-molecular weight drug) in human MCF-7 breast tumors of nude mice. We started to implement Task 4 which is devoted to in vivo studies of efficacy of cancer therapy with ultrasound-enhanced delivery of macromolecular anti-cancer drug Interleukin-2 (anti-cancer drug with high molecular weight). We partially conducted these studies to implement the proposed tasks. Our data obtained during these chronic experiments indicate that this technique may significantly improve breast cancer therapy. We have found that volume of ultrasound-irradiated tumors decreases when mice are injected with anti-cancer drug in combination with cavitation-mediating agent, while non-irradiated tumors of same mice grow. No improvement in cancer therapy was obtained when no cavitation-mediating agent was used. These results are very encouraging. To complete these studies, we requested a no-cost extension which was granted. The proposed studies will be implemented by the end of the project.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2004
- Accession Number
- ADA435264
Entities
People
- Rinat O. Esenaliev
Organizations
- University of Texas Medical Branch