Pulsed Electric Fields for Biological Weapons Defense
Abstract
The project has demonstrated that ultra-short, high-field pulses are a useful tool for study of cellular responses. The research has established that intracellular effects including apoptosis can be induced by the application of short, intense (but low total energy) electric pulses, and has seen variability in cell response. Experiments on human cells have produced convincing evidence that these applied fields nondestructively alter subcellular processes and can be investigated using biophotonic studies for imaging of morphological and functional changes at subcellular levels. In particular, it is clear that there are a range of responses to intense, ultra-short pulses, and that many lines of spores and cells require study. Technology for the application of pulses has been developed, and results of studies of toxicity have been undertaken, including detailed studies of Bacillus atrophaeus (formerly Bacillus subtilis var. niger).
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2002
- Accession Number
- ADA435273
Entities
People
- Martin A. Gundersen
Organizations
- University of Southern California