The Scaffold Attachment Factor SAFB1P: A New Player in G2/M Checkpoint Control
Abstract
Loss of G2/M checkpoint plays an important role in tumorigenesis, however, few genes involved in this checkpoint control have been shown to be deregulated in human breast tumors. SAFB1 is a multifunctional protein which maps to a locus of high LOH, and mutations have been identified from both breast cancer -cell lines and tumors. Our preliminary data show that inactivation of SAFB1 in MEFs result in loss of G2/M checkpoint control, and that loss of SAFB1 expression is associated with Taxotere resistance in human breast tumors. We therefore hypothesize that SAFB1 is critical for G2/M checkpoint control, and that its inactivation results in resistance to breast cancer therapies that utilize a block in G2/M and subsequent apoptosis. We will identify the mechanism by which SAFBl controls the G2/M checkpoint, and will subsequently analyze whether Taxotere-resistant tumors show altered expression of genes involved in these pathway(s).
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2005
- Accession Number
- ADA435280
Entities
People
- Steffi Oesterreich
Organizations
- Baylor College of Medicine