Non-Invasive Monitoring for Optimization of Therapeutic Drug Delivery by Biodegradable Fiber to Prostate Tumor
Abstract
Chemotherapeutic drugs delivered by systematic administration exhibit a great toxicity; patients have to endure the suffering from frequent injection. Thus, chronic and controlled release of chemotherapeutic drugs from biodegradable fibers implanted within the prostate tumor stroma will be a superior treatment modality. Furthermore, non-invasive and real-time monitoring of dynamic response and chronic changes of the tumors to therapeutic interventions will help researchers better understand the therapeutic process, and manipulate and optimize the therapeutic outcome. The hypotheses of this study are as follows: (1) a near-infrared (NIR) imager can noninvasively monitor the dynamic and chronic distribution of chemotherapeutic drug, vascular oxygenation, and blood volume in prostate tumors; and (2) the dynamic response of prostate tumor oxygenation to chronic drug delivery through the biodegradable fibers can serve as an indicator for treatment prognosis. The specific aims of the study were as follows: (1) design and implement an NIR spectroscopic imaging system suitable for dynamic imaging of drug concentrations, tumor oxygenation, and tumor blood volume; (2) develop a 2D tomographic reconstruction algorithm so as to obtain 2D tomographic images of tumor vascular oxygenation and the drug concentration delivered through the biodegradable fibers; (3) load therapeutic drugs onto the biodegradable fibers and control the dosage and releasing rate; and (4) study the relationship among the drug release rate, tumor oxygenation changes, and the therapeutic outcome to obtain optimal conditions in drug delivery.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2005
- Accession Number
- ADA435303
Entities
People
- Yueqing Gu
Organizations
- University of Texas at Arlington