Development of Anti-Cancer Therapeutics That Modulate the RAD51-BRCA2 Complex
Abstract
Cancer is one of the leading causes of death in America and breast cancer is particularly threatening for women. In America 10% of women will be diagnosed with breast cancer resulting in the death of more than 40,000 of these women each year. Inheriting a single defect in genetic material causes about 5% of the cases of breast cancer. A gene that is commonly mutated in these inherited cases of breast cancer is called BRCA2 (Breast Cancer susceptibility gene). BRCA2 is called a tumor suppression gene because its function is essential for preventing cancer, as a result deletion of this function predisposes women to breast cancer. BRCA2 is important for repairing damage to genetic material, DNA, by virtue of its association to RAD51. The BRCA2-RAD51 complex repairs broken DNA and disruption of this interaction may predispose a woman to breast cancer. This work defines the RAD51-Brca2 interaction.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2005
- Accession Number
- ADA435492
Entities
People
- Edward P. Hasty
Organizations
- University of Texas Health Science Center at San Antonio