Advances in Biomagnetic Interfacing Concepts Derived from Polymer-Magnetic Particle Complexes
Abstract
Our research on the development and characterization of magnetic nanoparticle-polymer complexes for tile project period 6/1/03-12/31/04 has yielded approximately 10-nm diameter cobalt particles coated with graphitic or silica protective shells to prevent oxidation of the particle surfaces. The specific saturation magnerizations of the protected particles range from 50-112 emu g, which is up to about five times the response of our previous nanoparticle materials. Oxidative durability results demonstrate that both classes of systems yield oxidatively-stable cobalt nanoparticles in air or water. However, the graphitic coatings are significantly more mechanically robust relative to the silica coatings. By contrast, the silica coatings can be readily functionalized with desirable functional groups. Collaborations with Prof. St. Pierre's biophysics group in Australia have been valuable to understand tile material and magnetic properties of these new materials. Accomplishments during this project also include a method for preparing magnetite microspheres with the biodegradable polymer, poly(L-lactide), strongly adsorbed onto the particle surfaces. The magnetite nanoparticles for this research are 4.8 nm in radius (by dynamic light scattering), and are superparamagnetic. Efforts with the magnetite-polymer complexes have been coordinated with Drs. Rosengart (U. Chi.) and Kaminski/Mertz (Argonne), and will continue as we jointly learn how to tailor surfaces to avoid immune response and to complex with biospecific groups.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2005
- Accession Number
- ADA435766
Entities
People
- Judy S Riffle
Organizations
- Virginia Tech