Imaging Metastatic Prostate Cancer After Genetic Manipulation of Transcriptional Memory Regulators EZH2 and EED
Abstract
This project is intended to explore the role of polycomb group protein EZH2 and its binding partner EED in metastatic prostate cancer. Both proteins will be introduced and overexpressed independently overexpressed in prostate cancer xenograft models by lentiviral transduction. Concordantly, the effects of reduced EZH2 or EED expression will be evaluated by RNAi technology. The growth and progression of the tumors will be monitored by optical imaging. The hypothesis is that EZH2 serves as a master regulator protein in prostate cancer metastasis; therefore, disruption of the balance between EZH2 and EED will result in a more aggressive disease phenotype. Exploration of the relationship between EZH2 levels and kinetics of dissemination of cancer cells will result in a better understanding of disease progression and appropriate treatment approaches.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2005
- Accession Number
- ADA435799
Entities
People
- Lily Wu
Organizations
- University of California, Los Angeles