Provisional Reference Dose for the Aromatic Fraction of Jet Fuel: Insight into Complex Mixtures
Abstract
Previous efforts to define toxicity criteria for human health risk assessment of complex petroleum mixtures use health effects information for only a subset of the chemicals in such mixtures. The Total Petroleum Hydrocarbon Criteria Working Group (TPHCWG) developed a practical alternative by defining all petroleum mixtures as thirteen carbon number range fractions based on expected transport characteristics following release to the environment. The TPHCWG developed toxicity criteria for each fraction using all available data, prioritizing mixture toxicity information. However, limited toxicity data were available to represent the fractions, including the EC>8 - EC16 aromatic fraction, which is believed to be one of the more toxic fractions. To address this data gap, a 90-day oral gavage toxicity study was conducted in female Sprague-Dawley rats and male CS7BL/6 mice to characterize toxic effects of the EC>8 - EC16 aromatic fraction of Jet Fuel A. Animals were dosed at 0, 20, 100 and 500 mg/kg/day.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2005
- Accession Number
- ADA435824
Entities
People
- David R. Mattie
- Donna J. Vohees
- John B. Green
- Peter B. Smith
- Teresa R Sterner
- Wade H. Weisman