Paracrine Regulation of Prostatic Carcinogenesis

Abstract

This report summarizes the work performed during this study. The long term goal of this project is to better understand why some prostate tumors grow aggressively while others are extremely slow growing lesions. The objective of the proposed research is to establish immortalized stromal cell lines denved from normal human prostate and from human prostate cancer and to use these cells to investigate the role of IGFs in prostate cancer growth. A number of new molecular tools were generated in the course of this project. A new technology (RNA interference) came into common use allowing us to suppress gene expression in a manner of technical complexity to overexpression of genes. We have been one of the first groups to be able to use this approach in tissue recombination models. As a result we have been able to identify the effects of suppression of IGF signaling in human prostate cancer cells in vivo as a mechanism to inhibit invasion and enhance differentiation.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2005
Accession Number
ADA435853

Entities

People

  • Simon W. Hayward

Organizations

  • Vanderbilt University Medical Center

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cancer
  • Carcinoma
  • Cell Line
  • Cells
  • Culture Techniques
  • Epithelial Cells
  • Gene Expression
  • Medical Personnel
  • Neoplasms
  • Prostate Cancer
  • Regulations
  • Standards
  • Stromal Cells
  • Tissues

Readers

  • Breast cancer cell signaling and growth regulation.
  • Molecular and genetic basis of cancer.
  • Prostate Cancer Biology.