Mechanism of tumor Metastasis Suppression by the KAI1 Gene
Abstract
Prostate cancer is the most frequently diagnosed cancer among men in the United States. It represents approximately 7% of all cancer deaths and ranks as the second leading cause of cancer death in males. The KAI1 gene was originally isolated as a prostate-specific tumor metastasis suppressor gene. Based on our preliminary data, we hypothesize that the KAI1 protein on tumor cells interacts with gp-Fy on the endothelial cells, which activates a signal-pathway of the KAIl molecule, and that this activation eventually leads to cell growth arrest of tumor cells. To test this hypothesis, we used gp-Fy knockout mice and injected prostate tumor cells that do or do not express KAIl gene. Our preliminary results indicate that the cancer cells expressing KAI1 are capable of attaching to vascular endothelial cells through direct interaction of KAI1 and gp-Fy proteins, and this interaction leads to inhibition of tumor cell proliferation. Our long-term goal is to elucidate the molecular mechanism of tumor suppression by the KAIl gene and to develop an effective therapeutic method which restores the function of the KAII gene in the metastatic tumor cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2005
- Accession Number
- ADA435979
Entities
People
- Kounosuke Watabe
Organizations
- Southern Illinois University