Generation, Sampling and Analysis of GB (Sarin) Vapor for Inhalation Toxicology Studies

Abstract

This study tested and optimized various methodologies to generate, sample and characterize GB test atmospheres in an inhalation chamber. A syringe drive spray atomization system was used for GB vapor generation. Stable GB test atmospheres (0.5 -50 mg/cu cm) were generated over different duration's (60, 240, 360 min) and sampled with solvent bubblers as well as an automated solid sorbent sampling system. Concentrations derived from each sampling method were compared against each other and statistically evaluated. A paired t-test showed no statistical difference between the two methods at the 95% confidence interval. Future applications include the ability to generate and monitor GB levels approaching the TLV-TWA of 0.0001 mg/cu cm.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2002
Accession Number
ADA436047

Entities

People

  • Charles L. Crouse
  • Lee C. Crouse
  • Leonard C. Buettner
  • Robert J. Mioduszewski
  • Sandra A. Thomas
  • Steven J. Anthony
  • William T. Muse

Organizations

  • Edgewood Chemical Biological Center

Tags

Communities of Interest

  • Counter WMD

DTIC Thesaurus Topics

  • Abstracts
  • Analyzers
  • Atmospheres
  • Atomization
  • Calibration
  • Chemical Warfare
  • Chemical Warfare Agents
  • Chromatographs
  • Control Systems
  • Demographic Cohorts
  • Detectors
  • Flow Rate
  • Generators
  • Mass Flow
  • Sampling
  • Standards
  • Vapors

Readers

  • Aerosol Science/Aerosol Physics
  • Neurotoxicology
  • Regression Analysis.