Neuroprotection for Nerve Agent-Induced Brain Damage
Abstract
This presentation will explain the rationale behind the neuroprotection Science Plan which has been established at the US Army Medical Research Institute of Chemical Defense as part of the medical chemical defense program. This program attempts to address a need that has not been specifically addressed before in any country, which is specifically to save vulnerable neurons that have been damaged due to seizures secondary to exposure to nerve agents. Preliminary work in this laboratory has demonstrated proof of concept using a compound not yet approved for clinical use by the US Food and Drug Administration. We will continue work with neuropathological correlation and add a neurobehavioral component to the testing program to be able to exploit preparations developed by industry, particularly in neuroprotection for stroke. If successful we will be able to give field physicians a new treatment with an excellent chance of minimizing or preventing neurobehavioral dysfunction after nerve agent poisoning, should primary protection against exposure and acute therapy of exposure both fail and status epilepticus ensue. We intend by presenting this program at this forum to stimulate Canadian and European colleagues to consider work in this area.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2002
- Accession Number
- ADA436048
Entities
People
- Gerald P. Ballough
- Jonathan Newmark
- Margaret G. Filbert
Organizations
- United States Army Medical Research Institute of Chemical Defense