The Potential Neurotoxic Effects of Low-Dose Sarin Exposure in a Guinea Pig Model

Abstract

This study is assessing the effects in guinea pigs of repeated low-dose exposure to the nerve agent sarin. Preliminary results suggest no effects of either repeated 0.2 or 0.4 X LD50 sarin exposure (compared with saline) on body weight or temperature, general physical signs, flinch threshold or activity level, or on EEG activity. In contrast, RBC cholinesterase levels dropped to 20% of baseline following the tenth exposure in the 0.4 group. Since this study is ongoing, data from receptor binding and brain cholinesterase assays and histopathology are still being collected and analyzed, and may be influenced by the dramatic changes in cholinesterase activity.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2002
Accession Number
ADA436057

Entities

People

  • John H. Mcdonough Jr.
  • Mary D. Gonzales
  • Melinda R. Roberson
  • Michelle B. Schmidt

Organizations

  • United States Army Medical Research Institute of Chemical Defense

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Animals
  • Biomedical Research
  • Body Temperature
  • Body Weight
  • Chemical Warfare
  • Contrast
  • Histology
  • Instructions
  • Intensity
  • Laboratory Animals
  • Nerve Agents
  • Rodents
  • Stainless Steel

Readers

  • Brain and Cognitive Science; Experimental Psychology; Cognitive Neuroscience
  • Immunology
  • Neurotoxicology