Control of Nerve Agent-Induced Seizures is Critical for Neuroprotection and Survival
Abstract
All six nerve agents studied were capable of producing prolonged seizures (status epilepticus) and neuropathology, and all 5 tested drugs were capable of terminating seizure activity. This presentation focused on the aspect of the influence of seizure activity, whether it was or was not terminated by any of the drug treatment, on neuropathological consequence and on mortality. Regardless of doses and drug treatment, control of seizure was strongly associated with protection against acute lethality and brain pathology, while failure to stop seizures was associated with increased lethality and more frequent and severe brain pathology. Thus, effective anticonvulsant treatment of a nerve agent casualty is critical to immediate and long-term recovery.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2002
- Accession Number
- ADA436059
Entities
People
- John H. McDonough
- S. M. Duniho
- T. M. Shih
Organizations
- United States Army Medical Research Institute of Chemical Defense