EGF Regulation of Nuclear Co-Activator AIB1 Function in Breast Cancer

Abstract

Various growth factor receptor pathways promote human breast tumorigenesis of hormone-independent tumors. The nuclear receptor coactivator AIB1 (amplified in breast cancer 1) can be phosphorylated and regulated by growth factor-induced signaling pathways such as MAP kinase and IkB kinase. Our lab has found a splice variant of AIB1, called delta exon3 ATB1, which has a higher co-activating ability than the full-length protein. This study determined the ability of delta exon3 splice variant compared with AIB1 in potentiating growth factor signaling and to determine the mechanism of this potentiation using a growth factor responsive promoter.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2005
Accession Number
ADA436895

Entities

People

  • Annabell S. Oh

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Apoptosis
  • Breast Cancer
  • Carrier Proteins
  • Cell Physiological Processes
  • Cells
  • Dna Microarrays
  • Growth Factors
  • Mammary Glands
  • Microarray Analysis
  • Neoplasms
  • Peptide Growth Factors
  • Proteins
  • Regulations
  • Tumor Cell Line

Fields of Study

  • Biology

Readers

  • Cardiovascular Physiology
  • Molecular Biology and Genetics