BRCA1 Protein Complexes: Dynamic Changes and Functions Important in Breast Cancer

Abstract

In the past year, I have made substantial progress towards completion of the tasks outlined in my Statement of Work. I have established a variety of stable cell lines, conducted preliminary purifications, and tested the functions of the BRCA1/BARD1 complex in in vitro assays for ubiquitination and transcription.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2005
Accession Number
ADA436903

Entities

People

  • Andrew A. Horwitz

Organizations

  • Harvard Medical School

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Anatomy
  • Antibodies
  • Biological Sciences
  • Biomedical Research
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Mass Spectrometry
  • Molecular Weight
  • Neoplasms
  • Proteins
  • Suppressors
  • Tissue Culture
  • Tissue Culture Cells
  • Transcription Factors

Readers

  • Breast cancer cell signaling and growth regulation.
  • Molecular and genetic basis of cancer.
  • Systems Analysis and Design