Regulated GDNF Delivery In Vivo using Neural Stem Cells

Abstract

In this progress report we show that human neural progenitor cells have been grown in culture, modified to release the potent growth factor GDNP, and survive transplantation into both the rodent and primate brain. In addition we have developed new PET techniques for monitoring the brain following GDNP delivery and produced new more efficient vectors for the regulation of GDNP. We feel that this progress is leading towards the potential use of the cells in clinical trials for patients and army veterans with Parkinson's disease.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2005
Accession Number
ADA436921

Entities

People

  • Clive N. Svendsen

Organizations

  • University of Wisconsin–Madison

Tags

DTIC Thesaurus Topics

  • Alzheimer Disease
  • Anti-Bacterial Agents
  • Biological Factors
  • Brain
  • Cells
  • Clinical Trials
  • Diseases And Disorders
  • Growth Factors
  • Neurodegeneration
  • Neurons
  • Parkinson'S Disease
  • Peptide Growth Factors
  • Peptides
  • Proteins
  • Spinal Cord
  • Stem Cells
  • Transplants

Readers

  • Aquatic Ecology
  • Medical Imaging.
  • Neuroscience

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech