Effects of Naturally-Occurring Estrogen-Fatty Acid Esters on Mammary Cell Growth and Carcinogenesis in Female Rats
Abstract
Research work completed thus far: (1) We have already evaluated the stimulatory effects of estradiol-17 beta-stearate on the growth of mammary vs. uterine cells in ovariectomized female Sprague-Dawley rats. Their effects have been compared with the effects of unesterified estradiol. (2) We have also determined the circulating levels of prolactin, FSH, and LH in all the animals. Right now we are still studying the growth-stimulatory effects of estradiol-17 beta-stearate and unesterified estradiol in pituitary, thymus, and liver of female rats. (3) We have completed comparing the carcinogenic activity of estradiol-17 beta-stearate and estradiol mammary vs. uterine cells in female ACI rats. We have also compared and correlated the differential carcinogenic activity of these two classes of estrogens with their differential growth stimulatory effects in various target organs. The results of our studies sheds light on the physiologic and pathophysiologic roles of endogenously-formed estrogen-fatty acid esters in the body. Also, our findings may lead to the development of new strategies to mammary cancer prevention through inhibition of esterase-catalyzed release of bioactive estrogen.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2004
- Accession Number
- ADA436922
Entities
People
- Won J. Lee
Organizations
- University of South Carolina