Dietary Fat, Eicosanoids and Breast Cancer Risk
Abstract
Epidemiological and animal studies associate high levels of dietary fat with increased risk of sex hormone mediated cancer, such as breast cancer. A high intake of total fat and omega-6 fatty acids increases risk while omega-3 (n3) fatty acids are associated with risk reduction. Our proposal is testing the effect of dietary fat and fatty acids on sex hormone concentrations in post-menopausal women. The objectives are to evaluate 1) the effects of total fat and n3 intake on plasma and urinary sex hormone levels, 2) the relationship between plasma fatty acids and plasma and urinary sex hormones, and 3) the effects of total fat and n3 on the association between sex hormone concentrations and urinary prostaglandin E2 (PGE2). We are performing a randomized, Latin square-designed controlled feeding study testing High Fat, Low Fat, and Low Fat + n3 diets, each of 8 week duration. In order to determine the estrogenic effects of the diets, sex hormone endpoints will be measured reflecting availability, metabolism, and action. Plasma fatty acids fractions and urinary PGE2 will be measured to evaluate mechanistic effects. At present 14 women have been screened and 5 are currently enrolled in the trial. No data has yet been generated.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2005
- Accession Number
- ADA436929
Entities
People
- Susan K. Raatz
Organizations
- University of Minnesota