Defining the Molecular Actions of Dietary Fatty Acids in Breast Cancer: Selective Modulation of Peroxisome Proliferator-Activated Receptor Gamma
Abstract
Stark differences in the actions of lenoleic acid (LAA), an omega-6 fatty acid, and eicosapentaenoic acid (EPA), an omega-3 fatty acid, on breast cancer tumors have been described. We propose that transactivation of peroxisome proliferators-activated receptor gamma (PPAR-gamma) mediates the physiological effects of different dietary fatty acids on breast cancer. PPAR-gamma plays a role in the development and progression of breast cancer tumors. We have demonstrated that individual ligands of PPAR-gamma can selectively activate PPAR-gamma in three different ways. Selective activation of PPAR-gamma by a single ligand occurs between tissue types and between individual breast cancer cell lines. Also, unique ligands selectively activate PPAR-gamma within a single cell type. We propose that fatty acids will elicit their effects on breast cancer cells in a similar manner. The objectives of forth coming studies will be to assess the necessity of transactivation of PPAR-gamma by LAA and EPA in mediating the effects of fatty acids on breast cancer cells and to determine what effect this selective activation has on gene transcription. We hypothesize that LAA and EPA can selectively regulate gene expression profiles that favor either cellular differentiation or proliferation and that these effects are dependent on transactivation of PPAR-gamma.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2005
- Accession Number
- ADA437097
Entities
People
- Clinton D. Allred
Organizations
- University of Kentucky