ERalpha and ErbB-2 Cross-Talk in Mammary Turmorigenesis and Metastasis
Abstract
The induction of human breast cancer involves the complex interplay of hormones and growth factor Receptors. The major focus of our DOD sponsored research program is to investigate the interaction of the ERalpha and erbB-2 receptor in the induction of breast cancer. In addition, we are also interested in the involvement of ErbB-2 coupled signaling pathways such as c-Src and Akt-1 in ERalpha induced mammary tumors. To accomplish this we have recently derived transgenic mice that expressed high levels of ERalpha in the mammary epithelium. To explore the significance of erbB-2c-Src and Akt-1 in mammary tumor progression we have recently initiated intercrosses between mice expressing these signaling molecules in the mammary epithelium and the MMTV/ERalpha strains. The results of these analyses should provide important insight in the mechanism by which erbB-2 and ERalpha communicate in the induction of breast cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2005
- Accession Number
- ADA437144
Entities
People
- William Muller
Organizations
- McGill University