Influence of Bone Remodeling Inhibition on the Development of Experimental Stress Fractures

Abstract

Stress fractures result from repetitive loading and have been regarded as a mechanical fatigue-driven process. However, a number of studies indicate implicate increased bone remodeling in the pathogenesis of stress fractures. These experiments tested the hypothesis by pharmacological inhibition of bone remodeling will diminish the severity of the stress fracture and slow the accumulation of microdamage with resulting from chronic loading. Bisphosphonate (BIS) antiresorptive therapy was used to suppress remodeling in the rabbit tibial stress fracture model. BIS antiresorptive therapy reduced the extent of periosteal reactive bone, with the resulting fracture callus volume reduced by about 40 percent. Similarly, microdamage content in bone was reduced as well. These data are consistent with the hypothesis that bone remodeling contributes to the pathogenesis of stress fracture. We also report on the results of novel model for stress fracture healing. using adult rats, developed under the aegis of this program.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2004
Accession Number
ADA437496

Entities

People

  • Mitchell B. Schaffler
  • Robert D. Boyd

Organizations

  • Icahn School of Medicine at Mount Sinai

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Arm Bones
  • Bending Moments
  • Biomedical Research
  • Bone And Bones
  • Bone Diseases
  • Bone Fractures
  • Foot Bones
  • Health Services
  • Histological Techniques
  • Inhibition
  • Mechanical Properties
  • Osteogenesis
  • Soft Tissues
  • Stresses
  • Tissues
  • Wounds And Injuries

Readers

  • Immunology and Pathology
  • Materials Science (Mechanical Engineering).