Potentiation of T Lymphocyte Responses by Modulating NF-kB Activity in Dendritic Cells

Abstract

The goal of this investigation is to determine whether modulation of NF-kappa beta activity by genetic engineering of DCs can affect DC longevity and T cell stimulatory functions. The specific aims are: 1) To determine the effect of expression of constitutively-active IK beta (I kappa beta kinase) on nuclear NF-kappa beta levels in DCs, and on the longevity of DCs. 2) To determine beta expression on in vitro and in vivo T cell priming by DCs. Results from these studies may thus lead the way for development of approaches for enhancing DC survival and function, with the goal of generating potent anti-tumor immunity.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2004
Accession Number
ADA437633

Entities

People

  • Amer A. Beg

Organizations

  • Columbia University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Bone Marrow
  • Cells
  • Electronic Mail
  • Engineering
  • Gene Expression
  • Genetic Engineering
  • Immunity
  • Infection
  • Lymphocytes
  • Modulation
  • New York
  • Survival
  • T Lymphocytes
  • Wound Infections

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Electronics Engineering
  • Neuroscience

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech