Role of the p53 Tumor Suppressor Homolog, p63, in Breast Cancer
Abstract
P63 IS A MEMBER OF THE P53 GENE FAMILY, AND SHOWS STRUCTURAL AND FLINCTIONAL SIMILARITIES TO THE P53 TUMOR SUPPRESSOR. While p53,s role in breast carcinogenesis is well established, p63's involvement in this disease remains unclear. It has been shown that p63 is expressed in the myoepithelial cells of the breast, and that p63 is essential for mammary development. The main goal of this project is to investigate the potential role of 1)63 in breast cancer. Despite the homology to p53, p63's flinctions and mechanisms cannot necessarily be extrapolated from p53 paradigms. A key goal of this proposal is to compare and understand the mechanisms of transcriptional regulation by p63 versus p53. Do p53 and p63 have distinct or overlapping targets? We have made significant progress towards identying p63 DNA-binding sites. We are also developing siRNA systems for analyzing the consequences of p63 depletion. Together, the proposed studies should offer a comprehensive view of transcriptional regulation and DNA binding by the p53 gene family. We anticipate that these data will help us understand their individual and interactive flinctions, as well provide important insights into signaling pathways in cancer and development.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2005
- Accession Number
- ADA437662
Entities
People
- Annie Yang
Organizations
- Harvard Medical School