Nutritional and Genetic Determinants of Early Puberty
Abstract
Past studies suggest that early menarche, growth velocity, and specific hormonal patterns during breast development may be critical in determining risk of breast cancer later in life. Nutritional factors during childhood and puberty, and inherited genetic factors. are suspected to interact in modulating these early-life exposures. However, the biological processes involved remain poorly understood. We propose to test the relationships between nutrition, genetic factors, hormonal levels and early life events contributing to breast cancer risk in a unique cohort of 323 adolescent girls of Caucasian or Asian ancestry originally recruited for the Female Adolescent Maturation (FAM) Study. These girls were studied twice, 2 years apart, for dietary intake, body size and composition, sexual maturation, growth and bone density. Data collection will be extended by conducting a third examination and obtaining blood samples for DNA genotyping and hormone analysis. A cross-sectional sample of 140 additional girls will also be recruited. Most of the first year was devoted to developing protocols and study instruments. The study received all lRB approvals, including from the DOD Human Subjects Review Board in early December 2004. Recruitment started on 2/4105. To date, 10 new girls from Kaiser, and 11 girls from the cohort have been recruited. Six girls have completed their 2 visits at Kapiolani Clinical Research Center and have blood and urine collection appointments scheduled. Data entry and analysis have not begun.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2005
- Accession Number
- ADA437668
Entities
People
- Loic Lemarchand
Organizations
- University of Hawaiʻi System