Polyphenols and Prostate Cancer Chemoprevention

Abstract

Asians consuming a diet high in soy products have reduced incidence of clinically manifested prostate cancers. Likewise, Asians have a long history of drinking tea. Significant components of these two staples of the traditional Asian diet are the polyphenolic compounds. The primary polyphenols associated with prostate chemoprevention are the soy Isoflavone, genistein, and the tea catechin, (-)- epigallocatechin-3-gallate (EGCG). Another polyphenol that has recently received attention as a cancer suppressor is resveratrol, a component of grapes. The goal of this research is to investigate the potential of these 3 pure polyphenols1 alone and In combination, to protect against prostate cancer. In this manner, it may be possible to ingest moderate amount of each of these foods/chemicals, as opposed to mega amounts of one, and receive an additive or synergistic protective effect without adverse effects with possible elevated exposure.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2005
Accession Number
ADA437686

Entities

People

  • Coral A. Lamartiniere

Organizations

  • University of Alabama

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Adenocarcinoma
  • Androgen Receptors
  • Androgens
  • Antigens
  • Biological Sciences
  • Biomedical Research
  • Body Weight
  • Cancer
  • Drug Therapy
  • Estrogens
  • Growth Factors
  • Medical Personnel
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Proteins

Fields of Study

  • Agricultural and Food sciences

Readers

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Technology Areas

  • Biotechnology