Immunomodulation of Hyperthermia for Recurrent Prostate Cancer

Abstract

Currently, there is no curative treatment for recurrent prostate cancer (PC). Although, radiation therapy (RT) has been successful in the treatment of primary PC, it is not used to treat locally recurrent PC because of the high morbidity of pelvic reirradiation. Hyperthermia has undergone extensive study as a treatment for BPH and its safety is very well established. Our long-term goal is to develop hyperthermia as a tumoricidal therapy for recurrent PC. We propose a strategy for in situ tumor vaccination where PC cells release tumor antigens following local treatment with hyperthermia, while cytokine-stimulated dendritic cells (DCs) harvest these antigens to mount an effective tumor-specific immunity in vivo.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2005
Accession Number
ADA437721

Entities

People

  • Chandan Guha

Organizations

  • Montefiore Medical Center

Tags

DTIC Thesaurus Topics

  • Adenoviruses
  • Antigen-Presenting Cells
  • Apoptosis
  • Biomedical Research
  • Bone Marrow
  • Cancer
  • Cells
  • Cytokines
  • Heat Treatment
  • Immunity
  • Immunomodulation
  • Lymphocytes
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • T Lymphocytes
  • Therapy

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Immunology
  • Oncology and Biomarker-Based Cancer Detection.

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech