Stem Cells in Prostate

Abstract

This project aims to identify adult prostate stem cells, using tissue recombination technology. To date, we have successfully directed the differentiation of mouse and human embryonic stem (ES) cells as outlined in the original statement of work. We have shown pathologically and histologically that the resultant tissue recombinants are highly characteristic of mouse and human prostate. We have refined the technology so that we reliably get prostate-like tissues in the absence of spontaneous differentiation of ES cells into non-prostate like tissues. We are currently restrained by the technology associated with the transfection of human embryonic stem cells, but hope to complete all the tasks of the project during 2005. This work has been presented at a total of 6 meetings including both national meetings within Australia internationally in the USA. We plan to publish the initial findings early in 2005. Work is ongoing to tag and isolate epithelial cells from these tissues in order to identify the adult prostate stem cell.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2005
Accession Number
ADA437723

Entities

People

  • Gail P. Risbridger

Organizations

  • Monash University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Androgen Receptors
  • Androgens
  • Australia
  • Biomedical Research
  • Cells
  • Epithelial Cells
  • Epithelium
  • Molecular Weight
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Stem Cells
  • Stromal Cells
  • Tissues
  • Transfection

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics
  • Oncology (Cancer Research).
  • Oncology and Biomarker-Based Cancer Detection.

Technology Areas

  • Biotechnology