Rational Inhibitors of DNA Base Excision Repair (BER) Enzymes: New Tools for Elucidating the Role of the BER in Cancer Chemotherapy

Abstract

In this funding period we have completed Task 1 and 2 of the approved Statement of Work, which seek to develop useful inhibitor scaffolds for the DNA repair enzyme uracil DNA glycosylase (UDG) and determine their potency against human UDG. To these ends, we have rationally developed a potent DNA-based inhibitor and, through high throughput synthesis and screening, several small molecule inhibitors for human UDG. The small molecule inhibitors are expected to be cell permeable, and in conjunction with 5-fluorouracil, may have potential for anticancer therapy. This work has resulted in one publication during this funding period.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2005
Accession Number
ADA437740

Entities

People

  • Daniel J. Krosky

Organizations

  • Johns Hopkins University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biochemistry
  • Chemical Reactions
  • Chemical Synthesis
  • Chemistry
  • Chemotherapy
  • Dna Repair Enzymes
  • Energy Transfer
  • Enzymes
  • Escherichia Coli
  • Free Energy
  • Hydrogen Bonds
  • Inhibitors
  • Molecules
  • Nucleic Acids
  • Nucleotides
  • Resonance
  • Small Molecules

Fields of Study

  • Biology
  • Chemistry
  • Medicine

Readers

  • Molecular Genetics
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech