Summer Student Breast Cancer Research Training Program
Abstract
The purpose of the breast cancer research training program is to recruit and train potential future researchers in breast cancer research. From a total of 90 applications for summer research, we selected a total of five students. During the 12 week program, trainees attended seven lectures, participated in weekly research and lab meetings, and developed and carried out research projects under the supervision of a mentor Two projects addressed the effects of omega-3 lipids upon breast cancer cells. 0mega-3 lipids were found to decrease breast cancer-induced muscle cell proteolysis and to induce apoptosis in cancer cells. Methyl and ethyl forms of omega-3 lipids failed to induce apoptosis. Ganoderma lucidum, a Chinese mushroom, was found to inhibit breast cancer cell growth and decrease EGF receptor phosphorylation. C-reactive protein (CRP) and a CRP peptide were found to upregulate urokinase plasminogen activator in cancer cells. The final study evaluated the effect of inhibitors of the mitogen activated protein kinases. A specific inhibitor of ERK increased apoptosis in highly invasive breast cancer cells. The results of the summer projects contributed significantly to ongoing breast cancer research at Methodist Research Institute and have added new information to our understanding of breast cancer development and progression.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2005
- Accession Number
- ADA437756
Entities
People
- Gary P. Zaloga
Organizations
- Indiana University Health