The Role of MUC1 Cytoplasmic Domain in Tumorigenesis
Abstract
The overall aim of the research is to develop a better understanding of the role of MUC1 in breast cancer. Loss of Muc1 (mouse homologue of MUC 1) significantly reduces tumor progression in polyomavirus middle T antigen (PyV MT-induced mammary tumors. The high transforming activity of the PyV MT antigen depends on c-Src which has been shown to phosphorylate the cytoplasmic tail of MUC1. Our aim is to identify specific proteins that associate with MUC1 and induce signaling that potentiates tumorigenesis, specifically the modulation of c-Src activity and signaling in MMTV-PyV MT tumorigenesis. We have found that MUC1 and c-Src interact in PyV MT-induced mammary tumors. Our data provide insights into the possible mechanism for the significant delay in tumor progression that is observed in the absence of Muc1. We suggest that the interaction of Muc1 with c-Src, a key player in PyV MT transformation, promotes the binding of c-Src to its downstream targets and influences its intracellular localization. Other studies in the lab have shown that overexpressed MUC1 induces mammary gland tumors. We found that overexpressed MUC1 also inhibits mammary gland involution. These results suggest that MUC1 functions as a weak oncogene in the mammary gland.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2005
- Accession Number
- ADA437950
Entities
People
- Assah Al-marsri
Organizations
- Mayo Clinic Scottsdale