Bacillus anthracis Edema Toxin Inhibits Staphylococcus aureus Enterotoxin B Effects in Vitro: A Potential Protein Therapeutic?

Abstract

Various in vitro effects of staphylococcal enterotoxin B (SEB) on human peripheral blood mononuclear cells were mitigated by Bacillus anthracis edema toxin. In particular, levels of some SEB-induced cytokines (tumor necrosis factor alpha, gamma interferon) and chemokines (monocyte chemoattractant protein 1, macrophage inflammatory protein 1 alpha MIP-1alpha, MIP-1beta) were significantly diminished or even nonexistent, depending upon the timing of edema toxin administration. Overall, these results suggest a novel use of B. anthracis edema toxin against a bacterial superantigen.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2005
Accession Number
ADA438021

Entities

People

  • Bradley G. Stiles
  • Stephen F. Little
  • Teresa Krakauer

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Antigens
  • Bacteria
  • Biological Factors
  • Biological Toxins
  • Blood
  • Body Fluids
  • Cells
  • Chemistry
  • Cytokines
  • Diseases And Disorders
  • Immune System
  • Infection
  • Infectious Diseases
  • Lymphocytes
  • Proteins
  • Staphylococcus Aureus
  • Therapy

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology and Pathology
  • Microbial Pathology