A Novel Member of the Insulin-Like Growth Factor Binding Protein Superfamily in Prostate Cancer
Abstract
The insulin-like growth factors (IGFs) are potent mitogens for normal and cancerous prostatic cells. The IGFs are found complexed to IGF binding proteins (IGFBPs) which modulate IGF bioactivity, but also may themselves act in an IGF-independent manner. We have recently characterized a series of IGFBP-related proteins (IGFBP-rPs) which share homology with the IGFBPs in the amino-terminus, bind IGFs with low affinity, and regulate cell growth through both IGF-dependent and IGF-independent actions. This grant is directed at the study of IGFBP-rPs (also known as connective tissue growth factor) as a regulator of normal and malignant prostatic growth. The specific aims are to: 1) analyze IGFBP-rPs mRNA and protein expression and distribution in normal and malignant prostatic tissues; 2) determine the transcriptional, translational and post-translational regulation of IGFBP-rPs; and 3) determine the mechanisms by which IGFBP-rPs regulates prostatic growth.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2004
- Accession Number
- ADA438221
Entities
People
- Ron G. Rosenfeld
Organizations
- Oregon Health & Science University